The VOXEL.AI Solution
Combining multiple data types in a unique way provides novel information to assist clinicians and improve the management of many aspects of a patient's care.
What VOXEL will do for healthcare
We measure the impact of brain disease not previously visible with conventional diagnostics
What VOXEL will do for patients
Our analysis determines how your injury or disease will impact your brain to guide your recovery.
Brain Disorder & Injury
Economic Impact of Brain Disorders & Injury
Annual costs of major neurological diseases total $765 billion USD1
In Europe, brain disorders are more costly than cardiovascular disorders or cancer2
1. Gooch et al., 2017
2. DiLuca and Olesen, 2014
Human Impact of Brain Disorders & Injury
In the US, nearly 100 million people were affected by neurological disorders in 20113 and these numbers are growing with the aging population.4
Neurological disorders are the world’s largest cause of years of healthy life lost due to disability or death5
3. Gooch et al., 2017
4. GBD 2017 US Neurological Disorders Collaborators, 2020
5. GBD 2015 US Neurological Disorders Collaborators, 2017
Intake, Imaging & Evaluation
Current Standard Of Care
Although much of medical decision making depends on lab results and imaging findings, certain diagnoses rely solely on clinical opinion rather than a positive test result.
For example, this is the case for concussion. In the absence of confirmatory evidence, even the most experienced clinicians may have difficulty predicting a patients disease progression or recovery6
6(Saposnik et al., 2013)
The Future Of Care
The Voxel.AI solution integrates multiple imaging modalities to provide a comprehensive evaluation of the brain. With this more complete picture of a patient’s brain. A care team can make better and more timely decisions about a patient’s care. We are developing disease specific biomarkers that will aid in a patient’s diagnosis, monitor their recovery and guide their rehabilitation.
VOXEL.AI Comprehensive Imaging Analysis
Our evaluation melds the structural, functional and physiological evaluations and combines them with our eloquence map to determine the location, size and impact of an injury. These insights can be used to inform the level of care necessary for a patient and guide recovery.
Structure
We evaluate the quality and integrity of the grey matter nodes and white matter tracts throughout the brain.
Physiology
We measure the brain’s resting blood flow and vascular reserve to assess its metabolic health.
Function
We determine the strength of the functional connectivity between many regions of the brain.
Eloquence
Not all regions of the brain are equally important. Areas responsible for key functions like vision and speech are highly eloquent while surrounding regions comprise the quiet brain.
Grey Matter Organization - The grey matter is highly organized into functionally distinct regions. The size of a region has been related to performance in a related behavior. Our analysis uses a T1 anatomical image to segment the brain’s features and determine the volume of many different regions throughout the cortex.
White Matter Integrity - White matter is formed by highly organized tracts of bundled axons. The health of the white matter can be determined by measuring how water diffuses a tract using Diffusion Tensor Imaging. An injury or disease can disrupt integrity of the axons, altering the water’s path. Our analysis maps the health of the tracts to identify any areas of concern.
Functional Connectivity - The brain relies on a series of distributed networks that integrate specialized regions to perform the most complex tasks - perception, reasoning, coordination, memory and language. We assess these networks by comparing patterns in the BOLD MRI signal during activity and rest to understand the strength of the connections between regions.
Resting Blood Flow - A healthy brain requires a steady supply of blood. To measure blood flow, we use arterial spin labeling to track the movement of magnetized blood throughout the head. This measurement allows us to generate a map of the average flow to identify areas of concern that could impact the ability of that region to function normally and can indicate injury or disease.
Cerebrovascular Reactivity - Blood flow in the brain is highly regulated, responding continuously to changes in blood pressure, arterial gases, neural activity, etc. to maintain homeostasis. We measure the how much the blood vessels dilate in response to an elevation in arterial carbon dioxide. The ability of a vessel to dilate is an indicator of the health of the tissue.
Not all regions of the brain are equally important. Processing and transmission centers responsible for the most critical tasks are termed ‘highly eloquent’ while other regions are considered to be ‘quiet’ brain. Injury in the eloquent tissues will have a much greater impact on behavior than injury to quiet tissues.
Our evaluation melds the structural, functional and physiological evaluations and combines them with our eloquence map to determine the location, size and impact of an injury or disease. These insights can be used to inform the level of care necessary for a patient and guide recovery.
Diagnosis for Brain Recovery + Rehabilitation
Observations Of Residual Symptoms
After neurological injury, a period of waiting can ensue to determine how a patient is going to recover. After our evaluation, clinicians and patients have a better idea of their likely prognosis and this will impact goal setting as well as decisions related to location and type of rehabilitation
Rehab Evaluation
In addition to prognostic information, we provide information that can be used to focus rehabilitation
Recovery Stream
As a patient continues their recovery, monitoring scans could be used to track their progress
Diagnosis for Monitoring of Brain Disorders
Monitor treatment efficacy or disease progression
As neurological disorders become more prevalent, new therapeutics are constantly being developed. Once an experimental treatment is providing benefit in terms of easing symptoms or delaying progression of disease, establishing the mechanism of action is extremely important. Our solution can help to answer this question and could be an informative add on to clinical trials.
Begin experimental or established treatment
For many patients with a degenerative diagnosis, treatment can be a process of trial and error. It may take several attempts with different medications or other therapies to identify a treatment that provides relief and has the least amount of side effects.
The Benefits VOXEL.AI will bring:
To patients
More comprehensive and accurate information related to brain injury, with unprecedented detail related to structure, function, and physiology.
Ability to more accurately predict recovery potential.
Prescription of therapy that is specifically designed for the unique characteristics of the patient’s injury.
To providers
Expedited transitions of care based on more accurate insights that result in optimal utilization of critical resources and discharge velocity.
More accurate prescription of therapies or interventions that contribute to improved outcomes and more rapid recovery.
To payors
Ability to reduce payments through shortened hospitalizations
Ability to better manage costs through a more complete recovery and a shorter recovery timeline.
Avoidance of unnecessary or ineffective therapies that increase expense without improving outcomes.